生物制造与再生医学课题组,主要聚焦于生物材料及功能体系的设计和研发,研究和应用先进生物制造技术,用于探索组织损伤和修复、器官发育和进化、疾病发生和演变等方面的基本科学问题,并揭示和阐明这些生命活动运行的基本原则和作用机制,以解决临床生物医学难题,包括组织再生和重建,以及疾病的预测和诊疗等前沿交叉领域的研究。
·生物材料的合成及功能化:包括功能性生物高分子材料的合成及表征、生物高分子的功能化及智能响应性、组织特异性的生物高分子材料体系的构建等,着重于研究材料理化性能、生物相容性、材料与细胞相互作用以及体内植入评价等
·多尺度和多维度生物制造技术:主要涵盖生物打印、微纳成型、微流控、类器官、器官芯片等技术的研发和应用
·工程化组织、器官及疾病模型:涉及不同组织的仿生化设计和微环境影响、软硬组织的修复和再生、复杂血管化组织的构建和功能化、疾病微环境的体外重建、癌症发生和转移体外模型等方面的研究
[1]Y. Wang†,H. Cui†, Y. Wang, C. Xu, T. Esworthy, S.Y. Hann, C. Liu, M. Boehm, D. Mei, and L.G. Zhang*. 4D Printed Cardiac Construct with Aligned Myofibers and Adjustable Curvature for Myocardial Regeneration.ACS Applied Materials & Interfaces, 2021,13: 12746-12758.
[2]H. Cui, C. Liu, T. Esworthy, Y. Huang, Z. Yu, X. Zhou, H. San, S. Lee, S.Y. Hann, M. Boehm, M. Mohiuddin, J. Fisher,and L.G. Zhang*. 4D Physiologically Adaptable Cardiac Patch: A Four-monthin vivoStudy for the Treatment of Myocardial Infarction.Science Advances, 2020,6: eabb5067.*Selected as “an online rotator” in the issue, and featured in "Research highlight" of Nature.
[3]S. Miao†,H. Cui†, T. Esworthy, B. Mahadik, S. Lee, X. Zhou, S.Y. Hann, J. Fisher, and L.G. Zhang*. 4D Self-morphing Culture Substrate for Modulating Cell Differentiation.Advanced Science, 2020, 7: 1902403.* Inside back cover image.
[4]H. Cui, T. Esworthy, X. Zhou, S.Y. Hann, R. I. Glazer, R. Li, and L.G. Zhang*. Engineering A Novel 3D Printed Vascularized Tissue Model for Investigating Breast Cancer Metastasis to Bone.Advanced Healthcare Materials, 2020,9:1900924.*Backcover image.
[5]H. Cui, W. Zhu, Y. Huang, C. Liu, Z. Yu, M. Nowicki, S. Miao, Y. Cheng, S. Lee, X. Zhou, Y. Zhou, S. Wang, H. San, M. Mohiuddin, K. Horvath,andL.G. Zhang*. InVitroand InVivoEvaluation of 3D Bioprinted Small-diameter Vasculature with Smooth Muscle and Endothelium.Biofabrication, 2020, 12: 015004.*Rated as one of the most read papers in Biofabrication.
[1]L. Zhang, H. Cui, and W. Zhu. (2022) Vascularized Biphasic Tissue Constructs, US11213614B2 (授权).
[2]S.Y. Hann,H. Cui,andL. Zhang. (2022) 3D Printing of Biomimetic Flexible Multilayer Blood Vessels, U.S. 63/172,461. PCT/US2022/024094 (公开).
[3]S. Miao,H. Cui,andL. Zhang. (2022) 4D Printing Smart Culture Substrate for Controlling Cell Functions, U.S. 17/690, 966.PCT/US2020/051598 (公开).
[4]H. Cui, W. Zhu, B. HolmesandL. Zhang. (2020)Smart Release System for Growth Factor Delivery and Combined Bone andVescularGrowth, US10688223B2 (授权).
[5]H. Cui, W. Zhu, and L. Zhang. (2020) A Coaxial Needle for Fabricating AMulti-scale, Multilayer Blood Vessel or Vascular Network Employing 3D Bioprinting, US10857260B2 (授权).
博士研究生:生物医学工程(083100)
硕士研究生:生物医学工程(077700);生物医学工程(083100)
v本课题组热忱欢迎有志于生物材料、生物制造、组织再生及疾病诊疗等相关研究,具有扎实化学、材料学、生物学或医学等知识背景,以及良好英语能力和较强的实验动手技能的学生,报考博士、硕士研究生。
v诚挚欢迎具有生物材料、生物制造、再生医学等相关研究背景的博士青年才俊,加入课题组开展科学研究和合作。弘深青年教师条件及年薪待遇请具体参考学校人事处网站。